Prednisolone usage, biological agent usage, and higher RA stage were significant risk factors for cervical lesions in patients with RA. ConclusionsĬervical lesions were confirmed in 57 % of the patients. Prednisolone usage and femoral neck BMD were the risk factors for VS. Multivariate analyses showed that the risk factors for RA cervical lesions were prednisolone usage, biological agent usage, and higher RA stage. The cervical-lesion group had a younger age of RA onset, longer RA disease duration, higher RA stage, and lower femoral neck BMD than the non-cervical-lesion group. There were 79 patients with AAS, 31 with VS, and 41 with SAS. The cervical-lesion and non-cervical-lesion groups included 106 and 79 patients, respectively. We used multivariate logistic regression analyses to assess the risk factors for cervical lesions in patients with RA. Radiological findings, BMD, and clinical data on RA were collected. We assigned patients with AAS, VS, or SAS to the cervical-lesion group, and all other patients to the non-cervical-lesion group. RA cervical lesions included atlantoaxial subluxation (AAS), VS, and subaxial subluxation (SAS). One hundred eighty-five consecutive patients with RA who underwent both cervical plain radiography and bone mineral density (BMD) scanning were enrolled. ![]() Therefore, this study aimed to investigate the prevalence and risk factors for cervical lesions in patients with RA under current pharmacological treatments with biological agents, and to investigate the relationship between osteoporosis and VS development. ![]() 16, 2023.Few reports have described the association between rheumatoid arthritis (RA) cervical lesions and osteoporosis, especially in patients with vertical subluxation (VS) that could be induced by the collapse of lateral masses in the upper cervical spine. Diagnosis and differential diagnosis of axial spondyloarthritis (ankylosing spondylitis and nonradiographic axial spondyloarthritis) in adults. Treatment of axial spondyloarthritis in adults. Clinical manifestations of axial spondyloarthritis in adults. Rheumatology and the musculoskeletal system. National Institute of Arthritis and Musculoskeletal and Skin Diseases. The inflammation associated with ankylosing spondylitis increases the risk of heart disease in general. The inflamed aorta can enlarge to the point that it distorts the shape of the aortic valve in the heart, which impairs its function. Ankylosing spondylitis can cause problems with the aorta, the largest artery in the body. Vertebral fractures can put pressure on and possibly injure the spinal cord and the nerves that pass through the spine. Weakened vertebrae can crumple, increasing the severity of a stooped posture. Some people's bones weaken during the early stages of ankylosing spondylitis. See your health care provider right away if you develop these symptoms. One of the most common complications of ankylosing spondylitis, uveitis can cause rapid-onset eye pain, sensitivity to light and blurred vision. Fusion also can stiffen the rib cage, restricting lung capacity and function. Those parts of the spine become stiff and inflexible. ![]() This new bone gradually bridges the gap between vertebrae and eventually fuses sections of vertebrae. ![]() In severe ankylosing spondylitis, new bone forms as part of the body's attempt to heal.
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